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Issen attacks are powerful, but very tricky to execute. However, some enemies will telegraph their moves more obviously than others, making Issen attacks easier.
The ultimate aim of the Issen is to embrace danger in order to exploit an enemy's most powerful attacks.
While Awakened, it will become easier to perform Issen against all enemy attacks. Aside from grabs and unblockable attacks, this can be the perfect opportunity to turn your foe's attacks against them.